Relative mortality impact of different individual characteristics of novel regimens for the treatment of RS or RR TB.

<p>Characteristics and levels are defined in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002202#pmed.1002202.t001" target="_blank">Table 1</a>. Impact is measured as a relative change in TB mortality (RS TB regimen, A and B) or RR TB mortality (RR TB regimen, C and D) 10 y after introduction of the novel regimen, as illustrated in Fig 3. In A and C, the benefit of partially (striped bars) or fully (solid bars) optimizing only one aspect of a regimen, with the remaining characteristics meeting only minimal targets, is compared to the impact of a regimen that is fully optimized in all aspects. In B and D, the mortality reduction achievable by a regimen that fails to meet only one optimistic target (relative to mortality projections using standard regimens) is compared to mortality reduction with a regimen that meets all optimistic targets. Percentages need not sum to 100% due to synergy between multiple characteristics of the regimen. Error bars show the 95% UR for the impact of each fully optimized characteristic.