Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles - Fig 4

<p>A. Representative microphotographs from regions in the sonicated and control hemispheres at different time points after BBBD induced by microbubble-enhanced sonication at 0.55MPa. Staining intensity was clearly reduced at one, 24, and 48 hours, but not at 72 hours. Fig 4. B. Pgp staining intensity scores at different time points after FUS-induced BBBD at 0.55MPa. A comparison of Pgp immunostaining in sonicated and control hemispheres revealed statistically significant differences in animals that were sacrificed one, 24 and 48 hours after BBBD (p<0.05, p<0.05, p<0.01, respectively), but not at 72 hours (p = 0.43). Scale bar: 40 μm.