<p>A. NDAPH level detected in control cells, IDH1 wild type stable cells and IDH1 R132H mutant stable cells. IDH1 R132H mutant vs. control (P<0.05). B. GSH level detected in control cells, IDH1 wild type stable cells and IDH1 R132H mutant stable cells. IDH1 R132H mutant vs. control vs. IDH1 wild type (p<0.05).</p
<p>The phosphorylation of the mature 130 kDa form (top bands) is higher for the mutant, despite the ...
[Urea]1/2 and [GdnHCl]1/2 midpoints of different LZ2 mutants as determined by CD spectroscopy.</p
Percent cell inhibition of DXH, EpiDXH and DNR against (a) H-1299 and (b) H-157 cell lines.</p
<p>A. Western blotting was performed to detect activated P-AKT and p-mTOR, total AKT and mTOR in sta...
Objective: A high percentage of grade II and III gliomas have mutations in the gene encoding isocitr...
Summary: Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute...
Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast ...
Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of ...
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumor...
IDH1 mutant enzyme does not affect glucose labeling of nucleotide precursors. Cells were treated and...
<p>NAD, NADH, NADP and NADPH in each cell line were quantitatively determined at 24, 48 and 72 hours...
<p>A) Strip-plots summarize the logarithm of the concentration ratios of metabolites altered in muta...
<p><i>A</i>, H<sub>2</sub>O<sub>2</sub> treatment in the glucose condition results in significantly ...
<p>U87IDHwt and U87IDHmut cells (A) and NHAIDHwt and NHAIDHmut cells (B) were analyzed for expressio...
<p>Chemical structure of DMH1; (B) Western blotting for phosphorylated Smad1/5/8 in A549 cells treat...
<p>The phosphorylation of the mature 130 kDa form (top bands) is higher for the mutant, despite the ...
[Urea]1/2 and [GdnHCl]1/2 midpoints of different LZ2 mutants as determined by CD spectroscopy.</p
Percent cell inhibition of DXH, EpiDXH and DNR against (a) H-1299 and (b) H-157 cell lines.</p
<p>A. Western blotting was performed to detect activated P-AKT and p-mTOR, total AKT and mTOR in sta...
Objective: A high percentage of grade II and III gliomas have mutations in the gene encoding isocitr...
Summary: Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute...
Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast ...
Summary: Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) occur in multiple types of ...
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumor...
IDH1 mutant enzyme does not affect glucose labeling of nucleotide precursors. Cells were treated and...
<p>NAD, NADH, NADP and NADPH in each cell line were quantitatively determined at 24, 48 and 72 hours...
<p>A) Strip-plots summarize the logarithm of the concentration ratios of metabolites altered in muta...
<p><i>A</i>, H<sub>2</sub>O<sub>2</sub> treatment in the glucose condition results in significantly ...
<p>U87IDHwt and U87IDHmut cells (A) and NHAIDHwt and NHAIDHmut cells (B) were analyzed for expressio...
<p>Chemical structure of DMH1; (B) Western blotting for phosphorylated Smad1/5/8 in A549 cells treat...
<p>The phosphorylation of the mature 130 kDa form (top bands) is higher for the mutant, despite the ...
[Urea]1/2 and [GdnHCl]1/2 midpoints of different LZ2 mutants as determined by CD spectroscopy.</p
Percent cell inhibition of DXH, EpiDXH and DNR against (a) H-1299 and (b) H-157 cell lines.</p