Biological networks with switching dynamics.

<p>(A) The epigenetic switch model proposed by Dodd et al. (2007) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005100#pcbi.1005100.ref061" target="_blank">61</a>]. (B) The polarity regulatory model of Motegi et al. (2013) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005100#pcbi.1005100.ref063" target="_blank">63</a>]. (C) The septation initiation network asymmetry establishment model of Bajpai et al. (2013) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005100#pcbi.1005100.ref064" target="_blank">64</a>]. The middle panels show the respective models with the condensed network notation, in which each node (molecule) represents three forms: inactive, non-decided, and active (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005100#pcbi.1005100.g002" target="_blank">Fig 2</a>); the right panels show the behaviour of the models when initiated from equal initial conditions and simulated with equal parameter values (all rates = 1). On panels B and C, only three traces are visible, as they totally overlap with the other three traces.