Promoters and enhancers have a distinctive TF regulatory landscape.

<p>Co-binding (left) and enrichment of transcription factor binding sites (right) in chromatin states (GenoSTAN-Poilog-K562) for 101 transcription factors in K562 reveals TF regulatory modules with distinct binding preferences for promoters, enhancers and repressed regions. The co-binding is depicted as the frequency of binding sites of two TFs that co-occur in a chromatin state divided by the number of all binding sites of the two TFs (Jaccard index). For each TF, enrichments were normalized to sum up to 1 across all 18 chromatin states of GenoSTAN-Poilog-dataset 1.