Delayed Recrudescence of Viral Replication after Sequential Treatment with SB 9200 Followed by ETV is Associated with Expression Increases of Type I IFNs, Cytokine and ISGs in Liver.

<p>Changes in mean liver transcript levels of IFN-α, IFN-β, and IL-6 (top panels) and of CXCL10, OAS1 and ISG15 (bottom panels) in response to treatment with ETV followed by SB 9200 (A, C) or SB 9200 followed by ETV (B, D). Changes in mean serum WHV DNA relative to T₀ (pretreatment baseline) is plotted on the left y-axis. The mean liver transcript levels are plotted on the right y-axis. Error bars represent the standard error of the mean. Mean transcript levels for IFN-α, IFN-β and IL-6 in Groups 1 and 2 were significantly lower compared to week -1 (pretreatment baseline) at week 24 (all <i>p</i><0.05). Mean transcript levels for CXCL10 and ISG15 in Group 1 were significantly higher at weeks 4 and 24 (all <i>p</i><0.05). Mean transcript level for ISG15 in Group 2 was significantly higher at week 24 (<i>p</i><0.05). Mean transcript level for OAS1 in Group 1 was significantly higher at week 24 (<i>p</i><0.05).