Diterpenoid alkaloids from the root of <i>Aconitum sinchiangense</i> W. T. Wang with their antitumor and antibacterial activities

<p>A phytochemical study of the root barks of <i>Aconitum sinchiangense</i> W. T. Wang, a traditional Chinese herb medicine, led to the isolation of 15 diterpenoid alkaloids, including one new C₁₉-diterpenoid alkaloid, sinchiangensine A (<b>1</b>), whose structure was determined by spectral methods including 2D NMR. Additionally, sinchiangensine A and its known analogue <b>3</b> were first reported as potential antitumor and antibacterial diterpenoid alkaloids, which showed significant antitumor activities against tumour cells (HL-60, A-549, SMCC-7721, MCF-7 and SW480), with IC₅₀ comparable to cisplatin, and significant antibacterial activities against <i>Staphylococcus aureus</i> ATCC-25923 with MIC value of 0.147 and 0.144 μmol/mL, respectively.