Statistical comparison of brain network distances across filtering methods.

<p>Bar plots show the medians of distance between brain network properties of samples in the healthy and diseased group. Vertical bars denote lower and upper quartiles. Medians and quartiles are in normalized units (n.u.) for the sake of representation. Overall, the choice of the filtering method significantly affects distances between samples (Kruskalwallis tests, <i>P</i> < 0.01, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005305#pcbi.1005305.s011" target="_blank">S3 Table</a>). For all graph quantities, ECO tends to give significantly larger distances as compared to other methods (Tukey-Kramer post hoc tests, <i>P</i> < 0.05); in some isolated cases, no significant improvements are reported (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005305#pcbi.1005305.s012" target="_blank">S4 Table</a>). By construction, MST gives null distances for local-efficiency as there are no triangles in tree-like networks.