Genetic risk factors in OCD converge on corticostriatal synapse function.

<p>(A) Schematic of functional effects of OCD versus 1000 Genomes population control RNM’s. All control RNM’s supported synaptogenesis similar to WT Slitrk5 when expressed in HEK-293 cells (blue) while all OCD RNM’s impaired synaptogenesis (red). (B) Schematic of corticostriatal synaptic dysfunction identified in genetic studies of OCD. <i>PTPRD</i> is associated with OCD in GWAS and both <i>SLITRK5</i> and <i>SAPAP3</i> cause an OCD-like syndrome in knockout mice and contain rare OCD-associated mutations.