Age-related evolution of sub-regional changes in <i>Hdh</i>Q150 brains.

<p>To compare sub-regional changes over time, all MRI scans were co-registered to the 36 week time point as this represented the time point with the largest volume (9DOF) and the clinical horizon. This afforded a statistical comparison of tissue changes (decreases in cold colors, increases in warm colors) in either time direction for either WT or <i>Hdh</i>Q150 with a correction for multiple comparison (FDR with q<0.05). These results indicate a slower growth (cold colors) of striatum in <i>Hdh</i>Q150 animals with a greater decrease (cold colors) in striatum and cortical regions beyond the clinical horizon.