Heritability estimates compared to population heritability.

<p>Heritability estimates and population heritability as a function of <i>λ</i>: the mean effect size of a new deleterious mutation. Additive (A; orange) component of true heritability is calculated by multiplying the end point(<i>q</i> = 1) of the variance curves in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006573#pgen.1006573.g001" target="_blank">Fig 1</a> by the broad-sense heritability values summarized in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006573#pgen.1006573.s002" target="_blank">S1 Fig</a>. HE-regression and GREMLd estimates were obtained from random population samples (n = 6000). GREMLd analysis was performed in GCTA using genotype data that was either unfiltered or filtered to remove variants with MAF<0.01. Twin study estimates are directly calculated using MZ and DZ twin correlations from 64 sets of twin studies. Each study consisted of pooling 2000 MZ twin pairs and 2000 DZ twin pairs from each of 8 model replicates for a total of 64,000 individual phenotypes. Data are plotted as the median across replicate sets ± half the interquartile range. Shown are the additive co-dominant (AC), gene-based (GBR) incomplete multiplicative recessive (Mult. recessive (<i>h</i> = 0.25); iMR) and complete multiplicative recessive (Mult. recessive (<i>h</i> = 0); cMR) models.