Maximum growth rate of diploid strains in nystatin2 (above diagonal) and YPD (below diagonal).

<p>Points are the fitted least-squares means of the maximum growth rates, with closed circles determined in the mixed-effects model including only homozygous strains and open symbols from the model that includes heterozygous strains (open diamonds: double heterozygotes; open triangles: single heterozygotes that are wild type at the other gene; open circles: single heterozygotes that are homozygous mutants at the other gene). Points and bars are otherwise as in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002591#pbio.1002591.g003" target="_blank">Fig 3</a>. All symbols are colored intermediately according to genotype and arrayed along the <i>x</i>-axis so as to lie between the two strains that are genotypically most similar to it. Solid lines indicate significant comparisons in tests run including only homozygous strains, whereas dotted lines are nonsignificant comparisons. See <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002591#pbio.1002591.s004" target="_blank">S4 Fig</a> for statistical comparisons including heterozygous strains and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002591#pbio.1002591.g003" target="_blank">Fig 3</a> for further graphical details. In YPD, the homozygous comparison <i>erg3 erg5</i> versus <i>erg3</i> is not significant when outliers are included. Note that the point for <i>erg5/ERG5 erg6/erg6</i> was removed because it was later found to have lost heterozygosity at <i>ERG5</i>. All underlying raw data and analyses can be found in Dryad [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002591#pbio.1002591.ref032" target="_blank">32</a>].