Effects of C-terminal truncated and full length TFPI on the regulation of thrombin generation.

<p>Thrombin generation by 2 pM of tissue factor in TFPI deficient plasma reconstituted with increasing concentrations of A: full length TFPI or B: C-terminal truncated TFPI. Thrombin generation is shown at final concentrations of 0 nM TFPI (○); 0.05 nM (●); 0.1 nM (▲); 0.5 nM (△); 1 nM (■): 2 nM (□); and 4 nM (◆) and 6 nM (▯). C: Thrombin peak heights from panel A and B are shown as a function of concentration of full length TFPI (●) or C-terminal truncated TFPI (○). Averages of duplicates are shown.