Hp gene expression and five-year overall survival rate analysis in TCGA HCC patients.

<p>(A) The boxplot demonstrated Hp gene expression level between adjacent non-tumorous tissues and tumor tissues in TCGA HCC patients (<i>p</i> < 0.001). (B) The Hp expression plot showed a total of 316 HCC patients that are ordered by Hp mRNA expression values (RPKM) from the lowest to the highest. The X-axis represents the accumulative number of HCC patients and the Y-axis represents Hp expression value in RPKM. The dashed line shows optimal cut point which dichotomized HCC patients into high (red) and low (green) Hp expression groups. (C) The <i>p</i>-value plot displayed the survival significance of each potential cut point of Hp expression measurement. According to each cut point, HCC patients are dichotomized into high and low Hp expression groups, and are calculated by log-rank test for survival significances. The X-axis represents the accumulative number of HCC patients on the order same as the Hp expression plot in panel B and the Y-axis represents raw <i>p</i>-values on a log10 scale. The optimal cut point is colored in red and is indicated by dashed line. (D) The Kaplan-Meier plot of HCC survival analysis. HCC patients were dichotomized into low Hp expression group (n = 34) and high Hp expression group (n = 282). The Kaplan-Meier survival curve showed high tumor Hp expression group has increased five-year overall survival rate, comparing with low tumor Hp expression group in TCGA HCC patients (<i>p</i> < 0.001).