<p>The 24 stem cell pluripotency maintenance genes regulated by the 35 transcription factors (TFs) were obtained from mouse ChIP-seq data. A microarray data set of these pathway genes and TFs yielded from a time course in which the pluripotent cells were subjected to undirected differentiation were downloaded from ESCAPE web portal (<a href="http://www.maayanlab.net/ESCAPE/" target="_blank">http://www.maayanlab.net/ESCAPE/</a>). The three data sets were generated by adding the profiles of 100, 200, and 300 noise variables to the profiles of 35 TF genes for <i>in silico</i> experimental validation.</p
<p>(A) Schematic representation of primary screen and secondary validation screens using mouse embry...
Coordinating the expression of more than 20,000 human genes in the correct spatial and temporal patt...
<p>The left panel shows a plot of the AUC for the top motif reported by MotifSpec against the AUC fo...
Mammalian genes have multiple functions in time and space during embryogenesis, aging, and in health...
A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse embryon...
<div><p>A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse...
It is known that on-and-off transcription factors (TFs) regulations play crucial roles in differenti...
Pluripotency is a term in cell biology describing a unique state present in distinct stem cell lines...
Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC) pluripotency. H...
Pluripotent cells can be subdivided into two distinct states, the naive and the primed state, the la...
Publicly-available microarray data constitutes a huge resource for researchers in biological scienc...
Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. How...
Stem cell research has potential for a variety of medicinal uses. This thesis investigates the expre...
<p>Publicly available DNA microarray data for 20 different tissue/somatic cell and stem cell types w...
Abstract Background To facilitate deciphering underlying transcriptional regulatory circuits in mous...
<p>(A) Schematic representation of primary screen and secondary validation screens using mouse embry...
Coordinating the expression of more than 20,000 human genes in the correct spatial and temporal patt...
<p>The left panel shows a plot of the AUC for the top motif reported by MotifSpec against the AUC fo...
Mammalian genes have multiple functions in time and space during embryogenesis, aging, and in health...
A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse embryon...
<div><p>A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse...
It is known that on-and-off transcription factors (TFs) regulations play crucial roles in differenti...
Pluripotency is a term in cell biology describing a unique state present in distinct stem cell lines...
Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC) pluripotency. H...
Pluripotent cells can be subdivided into two distinct states, the naive and the primed state, the la...
Publicly-available microarray data constitutes a huge resource for researchers in biological scienc...
Pluripotency maintenance and exit in embryonic stem cells is a focal topic in stem cell biology. How...
Stem cell research has potential for a variety of medicinal uses. This thesis investigates the expre...
<p>Publicly available DNA microarray data for 20 different tissue/somatic cell and stem cell types w...
Abstract Background To facilitate deciphering underlying transcriptional regulatory circuits in mous...
<p>(A) Schematic representation of primary screen and secondary validation screens using mouse embry...
Coordinating the expression of more than 20,000 human genes in the correct spatial and temporal patt...
<p>The left panel shows a plot of the AUC for the top motif reported by MotifSpec against the AUC fo...