Prenatal rrRSV exposure is associated with increased postnatal NGF expression.

<p>(A) Maternal rrRSV infection significantly increased NGF expression in offspring compared to RSV-naïve controls both in the presence (RR vs. CR) and absence (RC vs. CC) of postnatal rrRSV LRTI. (B) BDNF levels did not increase because of prenatal rrRSV exposure, regardless of postnatal rrRSV LRTI status (CC vs. RC or RR), whereas postnatal rrRSV inoculation was associated with significantly increased BDNF in the absence of prenatal rrRSV exposure (CR vs. CC). Data for 3 experiments were combined and expressed as the mean ± SEM of 10 rats per group. Two-tailed student’s <i>t</i> test: *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 as shown in Fig 6A or compared to the CR group in Fig 6B.