Ncls targets skeletal muscle to up-regulate signature genes of slow-twitch fibers in HFD mice.
- Sofi G. Julien (368524)
- Sun-Yee Kim (770305)
- Reinhard Brunmeir (249565)
- Joanna R. Sinnakannu (3752830)
- Xiaojia Ge (3752833)
- Hongyu Li (1332669)
- Wei Ma (299083)
- Jadegoud Yaligar (538172)
- Bhanu Prakash KN (643574)
- Sendhil S. Velan (464870)
- Pia V. Röder (527572)
- Qiongyi Zhang (660838)
- Choon Kiat Sim (660840)
- Jingyi Wu (1472761)
- Marta Garcia-Miralles (716034)
- Mahmoud A. Pouladi (3752827)
- Wei Xie (16543)
- Craig McFarlane (518108)
- Weiping Han (198991)
- Feng Xu (89016)
DOIAbstract
<p>(A) Hierarchical clustering of the 1,532 DEGs (> 2-fold change) in liver, WAT, BAT, and quadricep muscles of NCD-veh, HFD-veh, and HFD-ncls mice. (B) Most of the ncls up-regulated genes in quadricep muscles of HFD mice were also highly expressed in NCD-veh mice. (C) Most of the ncls down-regulated genes in quadricep muscles of HFD mice were also expressed at a lower level in NCD-veh mice as compared with HFD-veh mice. The percentages of overlapping genes among the up- and down-regulated genes in HFD-ncls mice were indicated in (B) and (C). Gene ontology analyses of the overlapping (D) 150 up-regulated and (E) 86 down-regulated genes in quadricep muscles. (F) Expression patterns of the ncls up-regulated genes in the “muscle protein” categ...