Kaplan-Meier Survival Curves of C57BL/6J Mice (n = 30/group), GI irradiated with 15.7 Gy (LD50/30).

<p>Twenty four hours after irradiation and daily for 7 days, mice were treated as indicated with 3 mg/kg unformulated FGF4, 3 mg/kg unformulated FGF7, 3 mg/kg PF4, 3 mg/kg PF7, PF4/7 which is 1.5 mg/kg PF4 plus 1.5 mg/kg PF7, or 60 mg/kg PGC carrier. Amifostine (300 mg/kg) used as a positive control was administered once 30 min prior to irradiation, and the sham irradiated control group remained untreated. Compared to the sham irradiated control (60% survival), significant survival advantage (≥90% survival) was provided by PF7, PF4, or unformulated FGF7 [p<0.02 by both Log-rank (Mantel-Cox) and Chi-square tests]. PF4, PF7, and Amifostine are not significantly different in preventing animal death. The PF4 and PF7 treated groups have higher survival than unformulated FGF4 or FGF7.