Immunostaining of the thoracic cage and lung parenchyma in <i>Pdpn</i><sup>KO1st</sup> mice for podoplanin (PDPN).
- Kenyo Takara (3769261)
- Naoki Maruo (2541937)
- Kyoko Oka (403666)
- Chiaki Kaji (3769255)
- Yuji Hatakeyama (565407)
- Naruhiko Sawa (3769252)
- Yukinari Kato (2825561)
- Junro Yamashita (3769258)
- Hiroshi Kojima (752596)
- Yoshihiko Sawa (565405)
Publication date
February 2017
DOIAbstract
<p>In the hematoxylin-eosin (HE) staining, atrophy is observed in the <i>Pdpn</i><sup>-/-</sup> mice. The expression of podoplanin (arrowheads) is observed in the lung of the wild type <i>Pdpn</i><sup>+/+</sup> mice and <i>Pdpn</i><sup>+/-</sup> mice, but not in the <i>Pdpn</i><sup>-/-</sup>. It is observed that the PDPN-positive areas are the mesothelia (arrowheads) of diaphragmatic pleura, costal pleura, and visceral pleura. It is also observed that costal bone (arrows) and lung parenchyma (asterisks) are PDPN positive. Staining densities of parenchyma PDPN are weaker in the <i>Pdpn</i><sup>+/-</sup> mice than in the <i>Pdpn</i><sup>+/+</sup> mice. Bar: 1 mm.</p
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