Slick/Slack concatemeric channels.

<p>A Slick/Slack concatemeric subunit was constructed by the junction of the C-terminus of the Slick channel sequence with the N-terminus of Slack as represented in (A) and expressed in <i>Xenopus laevis</i> oocytes. (B) Representative heteromeric Slick/Slack currents recorded during osmotic challenges, upon stimulation by a pulse protocol as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0169914#pone.0169914.g001" target="_blank">Fig 1</a>. (C) Summarized data of the effect of osmotic challenges on heteromeric channels. (D). I/V curves normalized to the maximal current for oocytes expressing the Slick/Slack concatemer or co-expressing homomeric Slick and Slack together with AQP1 (<i>n</i> = 10).