Possible correlation between the invariant density measure and clinical effectiveness of stimulation in OCD.

<p>Assessment of the mean ± standard error mean value of the invariant density measure based on a total of 39 MERs of subthalamic neuronal activity acquired during DBS surgery for treatment-refractory OCD and characterized by a high mean discharge rate (39.7 ± 14.71 Hz), a high intraburst frequency and a short interburst interval (μ_ISI = 0.0289 ± 0.0114s, Var_ISI = 0.0038 ± 0.0056) vs. a total of 39 MERs of subthalamic neuronal activity characterized by a low mean discharge rate (13.53 ± 7.13 Hz), a low intraburst frequency and a long interburst interval (μ_ISI = 0.1072 ± 0.093s, Var_ISI = 0.0265 ± 0.0542). The mean desynchronizing effect of standard 130Hz stimulation proved to be significanlty stronger in the former case compared with the latter (*<i>p</i>< 0.01, Mann—Whitney U test).