Hypothalamic over-expression of VGF attenuates body weight gain, whilst increasing food intake; a consequence of increased meal duration.

<p>Adult male Siberian hamsters received bilateral infusion of either AAV-GFP (control, GFP) or AAV-VGF-GFP (treated, VGF), with bodyweight (in grams) (A) and food intake (grams per gram body weight) (B) determined over the 12 weeks in home cages; while meal duration (C and D) and meal frequency (E and F) were determined over a 24hr period in metabolic cages at 2 (C and E) and 12 weeks (D and F) post-infusion. Values are group mean ±SEM, n = 3–4 per treatment, interaction **** p<0.0001; effect of treatment * p<0.05.