Rat models of advanced cirrhosis, portal hypertension, and renal dysfunction.
- Victoria K. Snowdon (3801049)
- Neil J. Lachlan (3801061)
- Anna M. Hoy (525368)
- Patrick W. F. Hadoke (206485)
- Scott I. Semple (312056)
- Dilip Patel (3801043)
- Will Mungall (3801058)
- Timothy J. Kendall (3801022)
- Adrian Thomson (3801037)
- Ross J. Lennen (3108276)
- Maurits A. Jansen (287659)
- Carmel M. Moran (3801019)
- Antonella Pellicoro (3801064)
- Prakash Ramachandran (3801025)
- Isaac Shaw (3801016)
- Rebecca L. Aucott (3801031)
- Thomas Severin (3801055)
- Rajnish Saini (3801052)
- Judy Pak (3801034)
- Denise Yates (3801046)
- Neelesh Dongre (3801028)
- Jeremy S. Duffield (335478)
- David J. Webb (229837)
- John P. Iredale (515057)
- Peter C. Hayes (2839478)
- Jonathan A. Fallowfield (3801040)
DOIAbstract
<p>Portal pressure (PP; A), renal blood flow (RBF; B), and glomerular filtration rate (GFR; C) in 16-wk CCl<sub>4</sub> and olive oil (OO) control rats (<i>n =</i> 6–11). Representative H&E-stained kidney (scale bar 50 μm) showing minor tubular epithelial cell vacuolation (arrows) without significant necrosis after 16 wk of CCl<sub>4</sub> (D). PP (E), RBF (F), and GFR (G) in bile duct ligation (BDL) and sham-operated (sham) control rats (<i>n =</i> 4–8). Representative H&E-stained kidney (scale bar 50 μm) showing necrotic cells within the tubule lumen and loss of the normal circumferential epithelial cell population (arrows) 4 wk after BDL (H). Data presented as mean ± standard error of the mean, analyzed by one-way ANOVA with post hoc Bon...
