Effect of mangiferin treatment on muscle fiber-size and serum levels of inflammatory cytokines in obese rats.

<p>Mean lesser fiber diameters of soleus (A) and tibialis cranialis (B) muscle fiber-types, and plasma levels of interferon-γ (IFN- γ) and interleukin (IL)-1β, IL-6 and IL-10 (C) were determined in lean (<i>FA</i>/<i>Fa</i> or <i>FA</i>/<i>fa</i>) Zucker rats and obese (fa/fa) Zucker rats that were treated with either placebo (Obese Placebo) or 15 mg/kg BW/day of Mangiferin for 8 weeks (Obese Mangiferin). For clarity, muscle fiber-types with a percentage below 5% (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173028#pone.0173028.g004" target="_blank">Fig 4</a>) are excluded. Values are means ± SD, n = 20 rats/group in A and B, n = 10 rats/group in C. * P < 0.05 vs Lean, # P<0.05 vs Obese Placebo (one-way ANOVA with Fisher LSD post-hoc test).