Sesquiterpene constituents from the soft coral <i>Sinularia nanolobata</i>

<p>Using various chromatographic separations, four sesquiterpenes (<b>1</b>–<b>4</b>), including two new compounds, nanolobatols A and B (<b>1</b> and <b>2</b>), were isolated from the Vietnamese soft coral <i>Sinularia nanolobata</i>. Their structures were determined on the basis of spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC, ¹H–¹H COSY, NOESY and FT-ICR-MS) and by comparison with the literature values. The cytotoxic activity of isolated compounds against a panel of eight human cancer cell lines was also evaluated.