<p>Multistage clonal expansion models are continuous-time Markov chain models in which normal cells undergo a series of genetic changes that lead to a state of clonal expansion followed by progression to malignancy.</p
N normal stem cells of colonic crypts are susceptible to a series of mutations with rates μ0 (K = 0)...
<p>(a) During each cell division, a mutation might arise which changes the fitness of a daughter cel...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Normal squamous epithelium may transform to BE with an exponentially distributed onset time with ...
<p>(A) Simulation with one malignant cell (increased proliferation rate <i>p</i>) initiated in the t...
<div><p>The availability of several methods to unambiguously mark individual cells has strongly fost...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
In this chapter, we will use multitype branching processes with mutation to model cancer. With cance...
<div><p>Many cancers are understood to be the product of multiple somatic mutations or other rate-li...
Cell proliferation and differentiation is described by a multi-type branching process, a probability...
<p>(A) The timesweep facet (top) shows the diagram of a prototypical transformed case in follicular ...
<p>Variation of the cumulative clone density in time for the cases: simulation with , simulation...
Multistep carcinogenesis through sequential cycles of mutation and clonal succession is usually desc...
N normal stem cells of colonic crypts are susceptible to a series of mutations with rates μ0 (K = 0)...
<p>(a) During each cell division, a mutation might arise which changes the fitness of a daughter cel...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Normal squamous epithelium may transform to BE with an exponentially distributed onset time with ...
<p>(A) Simulation with one malignant cell (increased proliferation rate <i>p</i>) initiated in the t...
<div><p>The availability of several methods to unambiguously mark individual cells has strongly fost...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
The availability of several methods to unambiguously mark individual cells has strongly fostered the...
In this chapter, we will use multitype branching processes with mutation to model cancer. With cance...
<div><p>Many cancers are understood to be the product of multiple somatic mutations or other rate-li...
Cell proliferation and differentiation is described by a multi-type branching process, a probability...
<p>(A) The timesweep facet (top) shows the diagram of a prototypical transformed case in follicular ...
<p>Variation of the cumulative clone density in time for the cases: simulation with , simulation...
Multistep carcinogenesis through sequential cycles of mutation and clonal succession is usually desc...
N normal stem cells of colonic crypts are susceptible to a series of mutations with rates μ0 (K = 0)...
<p>(a) During each cell division, a mutation might arise which changes the fitness of a daughter cel...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
DOI
Add to ORKG