Minimalistic kinetic models of possible ATP-driven H⁺ pump mechanisms.

<p>Coupling ratio of 3:1 H⁺:ATP is shown here. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173500#pone.0173500.s001" target="_blank">S1 File</a> for 2:1 coupling ratio. Two possible proton transport mechanisms, (a) rotary and (b) alternating access, based on one of six possible sequences of reactions (event orders) for nucleotide and phosphate binding/unbinding in the ATP-driven proton pumping cycle. Results are qualitatively similar for other event orders. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173500#pone.0173500.s001" target="_blank">S1 File</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0173500#pone.0173500.g004" target="_blank">Fig 4(b)</a>.