Herein, we describe a study into the scope and origin of an enantiodivergent effect in the palladium-catalyzed decarboxylative asymmetric protonation. By switching the achiral proton source, both enantiomers of a series of tertiary α-aryl-1-indanones are readily accessed from the corresponding α-aryl-β-keto allyl esters. In this example of dual stereocontrol, enantioselectivities up to 94% (<i>S</i>) and 92% (<i>R</i>) were achieved using Meldrum’s acid and formic acid, respectively. In an attempt to rationalize this switch in absolute configuration an investigation of the ambiguous mechanism of the decarboxylative asymmetric protonation was conducted. A novel catalytic cycle for the reaction with formic acid is proposed and subjected to a ...
International audienceAn asymmetric organocatalysed decarboxylative protonation reaction allowed a s...
The palladium-catalyzed decarboxylative allylic alkylation of enol carbonates derived from lactams a...
The density functional (M06) computations on a cooperative multicatalytic reaction involving palladi...
International audienceThe palladium‐catalyzed decarboxylative asymmetric protonation (DAP) of racemi...
General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tert...
We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary s...
The catalytic asymmetric synthesis of a series of tertiary α-aryl cyclopentanones and cyclohexanones...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of α-amino malonat...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of α-amino malonat...
The Pd-catalyzed decarboxylative asymmetric allylic alkylation of enolate nucleophiles is a cornerst...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of alpha-amino mal...
We describe herein the asymmetric synthesis of α-allyl carboxylic acids containing an α-quaternary s...
This account describes the circumstances leading to our group's innovations in the area of decarbox...
Dissertation (Ph.D.)--University of Kansas, Chemistry, 2007.The generation, and subsequent allylatio...
Chiral molecules exist in two different forms called enantiomers, which are non-superimposable mirro...
International audienceAn asymmetric organocatalysed decarboxylative protonation reaction allowed a s...
The palladium-catalyzed decarboxylative allylic alkylation of enol carbonates derived from lactams a...
The density functional (M06) computations on a cooperative multicatalytic reaction involving palladi...
International audienceThe palladium‐catalyzed decarboxylative asymmetric protonation (DAP) of racemi...
General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tert...
We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary s...
The catalytic asymmetric synthesis of a series of tertiary α-aryl cyclopentanones and cyclohexanones...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of α-amino malonat...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of α-amino malonat...
The Pd-catalyzed decarboxylative asymmetric allylic alkylation of enolate nucleophiles is a cornerst...
Mechanism and the origin of enantioselectivity in the decarboxylative protonation of alpha-amino mal...
We describe herein the asymmetric synthesis of α-allyl carboxylic acids containing an α-quaternary s...
This account describes the circumstances leading to our group's innovations in the area of decarbox...
Dissertation (Ph.D.)--University of Kansas, Chemistry, 2007.The generation, and subsequent allylatio...
Chiral molecules exist in two different forms called enantiomers, which are non-superimposable mirro...
International audienceAn asymmetric organocatalysed decarboxylative protonation reaction allowed a s...
The palladium-catalyzed decarboxylative allylic alkylation of enol carbonates derived from lactams a...
The density functional (M06) computations on a cooperative multicatalytic reaction involving palladi...