<p><b>(A)</b> Testosterone hydroxylation was determined in male and female WT and Cyp3a-null mice as described in the Materials and Methods. Data are presented as mean specific activity (μmol/min/mg protein) ± SEM (n = 4). <b>(B)</b> Ratio of 6α/15α-hydroxytestosterone as a biomarker of CYP sexual dimorphism in the liver. An <sup>a</sup>indicates a significant difference between WT male and Cyp2b9/10/13-null male mice, <sup>b</sup>indicates a significant difference between WT female and Cyp2b9/10/13-null female mice, <sup>c</sup>indicates a significant difference between male and female WT mice and <sup>d</sup>indicates a significant difference between the male and female Cyp2b9/10/13-null mice. Statistical differences were determined by tw...
Three enzymatic activities of the CYP2A subfamily, coumarin 7-hydroxylase (COH), testosterone 15α-hy...
Male and female mice and hamsters were decapitated 1-5 days after birth and serum concentrations of ...
Testosterone is the main reproductive hormone in male vertebrates and conventional methods to measur...
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption...
Liver drug metabolism was studied in adult mice to define sex-specific patterns of P450-dependent mo...
We have previously shown that sexual dimorphism in the expression of mouse renal cytochrome P450s is...
peer reviewedaudience: researcher, professionalSteroid 16 alpha-hydroxylase activities and propertie...
The impact of age and sex on the expression of hepatic cyto-chrome P450 3A4 (CYP3A4) was recently de...
We have studied the extent to which mouse renal cytochrome P-450 isoenzymes are sexually differentia...
<p>A. Activation of STAT5b function in testosterone-treated mouse liver. The STAT5b biomarker gene s...
<p>Testosterone levels in WT, Hemi, and Sickle mice were measured by RIA. Each bar represents the me...
Adult male rodents have a pulsatile profile of growth hormone (GH) release, whereas female rodents h...
The sex-dependent expression and inducibility of the cytochrome P450 2B subfamily was studicd in DBA...
<p>Five adult male miR-shRNA1 transgenic mice, unrelated miR-shRNA transgenic mice and wild-type mic...
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption...
Three enzymatic activities of the CYP2A subfamily, coumarin 7-hydroxylase (COH), testosterone 15α-hy...
Male and female mice and hamsters were decapitated 1-5 days after birth and serum concentrations of ...
Testosterone is the main reproductive hormone in male vertebrates and conventional methods to measur...
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption...
Liver drug metabolism was studied in adult mice to define sex-specific patterns of P450-dependent mo...
We have previously shown that sexual dimorphism in the expression of mouse renal cytochrome P450s is...
peer reviewedaudience: researcher, professionalSteroid 16 alpha-hydroxylase activities and propertie...
The impact of age and sex on the expression of hepatic cyto-chrome P450 3A4 (CYP3A4) was recently de...
We have studied the extent to which mouse renal cytochrome P-450 isoenzymes are sexually differentia...
<p>A. Activation of STAT5b function in testosterone-treated mouse liver. The STAT5b biomarker gene s...
<p>Testosterone levels in WT, Hemi, and Sickle mice were measured by RIA. Each bar represents the me...
Adult male rodents have a pulsatile profile of growth hormone (GH) release, whereas female rodents h...
The sex-dependent expression and inducibility of the cytochrome P450 2B subfamily was studicd in DBA...
<p>Five adult male miR-shRNA1 transgenic mice, unrelated miR-shRNA transgenic mice and wild-type mic...
Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption...
Three enzymatic activities of the CYP2A subfamily, coumarin 7-hydroxylase (COH), testosterone 15α-hy...
Male and female mice and hamsters were decapitated 1-5 days after birth and serum concentrations of ...
Testosterone is the main reproductive hormone in male vertebrates and conventional methods to measur...