<p><b>(A)</b> Two individual evolutions trees. Mutations in cancer-related gene are shown in colors corresponding to where they first appear. <b>(B)</b> Summary table of alterations in 35 pRCC WGS. Index: patient index, see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006685#pgen.1006685.s009" target="_blank">S2 table</a>.</p
<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090931#pone-0090931-g002" ...
<p>Boxes represent pseudogenes and the symbol “*”denotes pseudogenes that resulted from relatively r...
a<p>Branch names are denoted in phylogenetic tree in <a href="http://www.plosgenetics.org/article/in...
<p>Coding mutations in known cancer genes (A) and candidate genes (B) are indicated with different c...
<p>Only altered samples are shown. Rows are sorted based on the frequency of the alterations in all ...
<p>A summary chart of all mutations in each group displays genes across in rows and patient tumors d...
Cartoon diagrams of RAD52, BRCA2, BRCA1 and PALB2 showing specific domains in each gene. The diagram...
<p>(A) Somatic mutational landscape of 34 patients with HGSOC. Somatic mutations identified in more ...
<p>The sequences are stored in GenBank (accession numbers KC286583 –KC286589 corresponding to Lab005...
<p>(Panel A) Amount of SGA in biopsies (dots) and mean SGA over all biopsies at that time point (lin...
<p>Each panel shows the inferred clonal phylogeny assuming (A) , (B) , (C) and (D) clones, where C...
Abstract Cancer develops through a process of somatic evolution 1,2 .Sequencing data from a single b...
<p>All detected mutations in the chromosome of the ancestral cells, initially adaptive cells, and th...
Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy repr...
<p>The heatmap shows genes (rows) and tumors (columns) with mutations (blue). The number of events p...
<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090931#pone-0090931-g002" ...
<p>Boxes represent pseudogenes and the symbol “*”denotes pseudogenes that resulted from relatively r...
a<p>Branch names are denoted in phylogenetic tree in <a href="http://www.plosgenetics.org/article/in...
<p>Coding mutations in known cancer genes (A) and candidate genes (B) are indicated with different c...
<p>Only altered samples are shown. Rows are sorted based on the frequency of the alterations in all ...
<p>A summary chart of all mutations in each group displays genes across in rows and patient tumors d...
Cartoon diagrams of RAD52, BRCA2, BRCA1 and PALB2 showing specific domains in each gene. The diagram...
<p>(A) Somatic mutational landscape of 34 patients with HGSOC. Somatic mutations identified in more ...
<p>The sequences are stored in GenBank (accession numbers KC286583 –KC286589 corresponding to Lab005...
<p>(Panel A) Amount of SGA in biopsies (dots) and mean SGA over all biopsies at that time point (lin...
<p>Each panel shows the inferred clonal phylogeny assuming (A) , (B) , (C) and (D) clones, where C...
Abstract Cancer develops through a process of somatic evolution 1,2 .Sequencing data from a single b...
<p>All detected mutations in the chromosome of the ancestral cells, initially adaptive cells, and th...
Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy repr...
<p>The heatmap shows genes (rows) and tumors (columns) with mutations (blue). The number of events p...
<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090931#pone-0090931-g002" ...
<p>Boxes represent pseudogenes and the symbol “*”denotes pseudogenes that resulted from relatively r...
a<p>Branch names are denoted in phylogenetic tree in <a href="http://www.plosgenetics.org/article/in...