<p>Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to peroxynitrite was maintained during the development of atherosclerosis due to changes in the expression of calcium-regulatory proteins. In this study we investigated: (1) the mechanism of peroxynitrite-induced relaxation in the mouse aorta, (2) the effect of atherosclerosis on relaxation to peroxynitrite and other vasodilators, and (3) the effect of atherosclerosis on the expression and function of the IP3 receptor. Aortic function was studied using wire myography, and atherosclerosi...
<b><i>Objective:</i></b> Vascular calcification is highly correlated with cardiovascular disease mor...
Rationale: Peroxisome proliferator-activated receptor (PPAR) agonists attenuate atherosclerosis and...
Cardiovascular diseases are the leading cause of mortality in industrialized countries and their pre...
Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpo...
Relaxation of vascular smooth muscle (VSM) requires re-uptake of cytosolic Ca2+ into the sarcoplasmi...
AbstractObjectivesRelaxation of vascular smooth muscle (VSM) requires re-uptake of cytosolic Ca2+ in...
There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic ac...
Inositol 1, 4, 5-trisphosphate receptor-mediated (IP3R-mediated) calcium (Ca(2+)) release has been p...
This journal suppl. entitled: Special Issue: Abstracts of the 17th World Congress of Basic and Clini...
In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to the rel...
Hypertension is a major health problem in the United States, where more than 50 million people (1 in...
Open Access JournalWy14643 is a potent activator of peroxisome proliferator-activated receptor (PPAR...
Cardiovascular disease is the leading cause of death in the United States and globally. Aortic stiff...
Background: Regulation of vascular tone is complex. Various complementary signaling pathways causing...
We sought to determine direct vascular effects of peroxisome proliferator-activated receptor alpha (...
<b><i>Objective:</i></b> Vascular calcification is highly correlated with cardiovascular disease mor...
Rationale: Peroxisome proliferator-activated receptor (PPAR) agonists attenuate atherosclerosis and...
Cardiovascular diseases are the leading cause of mortality in industrialized countries and their pre...
Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpo...
Relaxation of vascular smooth muscle (VSM) requires re-uptake of cytosolic Ca2+ into the sarcoplasmi...
AbstractObjectivesRelaxation of vascular smooth muscle (VSM) requires re-uptake of cytosolic Ca2+ in...
There is strong evidence that the omega-3 polyunsaturated fatty acids (n-3 PUFAs) docosahexaenoic ac...
Inositol 1, 4, 5-trisphosphate receptor-mediated (IP3R-mediated) calcium (Ca(2+)) release has been p...
This journal suppl. entitled: Special Issue: Abstracts of the 17th World Congress of Basic and Clini...
In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to the rel...
Hypertension is a major health problem in the United States, where more than 50 million people (1 in...
Open Access JournalWy14643 is a potent activator of peroxisome proliferator-activated receptor (PPAR...
Cardiovascular disease is the leading cause of death in the United States and globally. Aortic stiff...
Background: Regulation of vascular tone is complex. Various complementary signaling pathways causing...
We sought to determine direct vascular effects of peroxisome proliferator-activated receptor alpha (...
<b><i>Objective:</i></b> Vascular calcification is highly correlated with cardiovascular disease mor...
Rationale: Peroxisome proliferator-activated receptor (PPAR) agonists attenuate atherosclerosis and...
Cardiovascular diseases are the leading cause of mortality in industrialized countries and their pre...