<p>RACIPE was tested on three circuits–a simple toggle-switch (TS, top left) which consists of genes A and B that mutually inhibit each other (solid lines and bars), a toggle-switch with one-sided self-activation (TS1SA) which has an additional self-activation link on gene A, and a toggle-switch with two-sided self-activation (TS2SA) which has additional self-activation links on both genes. <b>(A)</b> Probability distributions of the number of stable steady states for each circuit. <b>(B)</b> Probability density maps of the gene expression data from all the RACIPE models. Each point represents a stable steady state from a model. For any RACIPE model with multiple stable steady states, all of them are shown in the plot. <b>(C)</b> Average li...
Gene regulatory network is essential to regulate the biological functions of cells. With the rapid d...
The genetic bi-stable switch (toggle switch) consists of two genes which repress one another through...
A toggle switch consists of two genes that mutually repress each other. This regulatory motif is act...
<p>RACIPE was tested on coupled toggle-switch circuits, as illustrated at the top of the figure. <b>...
BACKGROUND: One of the major challenges in traditional mathematical modeling of gene regulatory circ...
One of the most important roles of cells is performing their cellular tasks properly for survival. C...
<div><p>One of the most important roles of cells is performing their cellular tasks properly for sur...
BACKGROUND: One of the major challenges in traditional mathematical modeling of gene regulatory circ...
Finding a multidimensional potential landscape is the key for addressing important global issues, su...
<p><b>(A)</b> Schematic of the procedure to estimate the ranges of the threshold parameters, so that...
The genetic bi-stable switch (toggle switch) consists of two genes which repress one another through...
Includes bibliographical references.2016 Summer.Biological switches are biochemical network motifs r...
Dual-state genetic switches that can change their state in response to input signals can be used in ...
We studied a simple gene regulatory network, the toggle switch. Specifically, we examined the means ...
<p>(<b>A–B</b>) Schematics of two types of group transition in response to changes in cell density. ...
Gene regulatory network is essential to regulate the biological functions of cells. With the rapid d...
The genetic bi-stable switch (toggle switch) consists of two genes which repress one another through...
A toggle switch consists of two genes that mutually repress each other. This regulatory motif is act...
<p>RACIPE was tested on coupled toggle-switch circuits, as illustrated at the top of the figure. <b>...
BACKGROUND: One of the major challenges in traditional mathematical modeling of gene regulatory circ...
One of the most important roles of cells is performing their cellular tasks properly for survival. C...
<div><p>One of the most important roles of cells is performing their cellular tasks properly for sur...
BACKGROUND: One of the major challenges in traditional mathematical modeling of gene regulatory circ...
Finding a multidimensional potential landscape is the key for addressing important global issues, su...
<p><b>(A)</b> Schematic of the procedure to estimate the ranges of the threshold parameters, so that...
The genetic bi-stable switch (toggle switch) consists of two genes which repress one another through...
Includes bibliographical references.2016 Summer.Biological switches are biochemical network motifs r...
Dual-state genetic switches that can change their state in response to input signals can be used in ...
We studied a simple gene regulatory network, the toggle switch. Specifically, we examined the means ...
<p>(<b>A–B</b>) Schematics of two types of group transition in response to changes in cell density. ...
Gene regulatory network is essential to regulate the biological functions of cells. With the rapid d...
The genetic bi-stable switch (toggle switch) consists of two genes which repress one another through...
A toggle switch consists of two genes that mutually repress each other. This regulatory motif is act...