Shorter telomere length profiles are observed in Barrett’s metaplasia but no differences are detected at four different chromosome ends.

<p>A, an example of STELA at the XpYp telomere in two patients with matched normal squamous epithelium (S), Barrett’s metaplasia (B) and normal gastric mucosa (G). The mean and standard deviation of telomere length profiles are detailed below. B, example of the same samples analysed with STELA at the 17p telomere. C-F, telomere length profiles obtained from patients #1-#8, as detailed above, depicted as scatter plots obtained by STELA at the telomeres of XpYp (C), 17p (D), 11q (E) and 9p (F). Statistically significant differences between the Barrett’s metaplasia samples with either patient matched squamous or gastric samples are illustrated with asterisks above the plots (two-tailed, Mann-Whitney; * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001 and **** P ≤ 0.0001), error bars represent 95% confidence intervals. Patients in which the Barrett’s metaplasia sample displayed the shortest, or equal shortest, telomere-length profiles are highlighted in green. G, scatter plot displaying the mean telomere lengths determined for each chromosome end, error bars represent SD.