Representative experiment of NPS reducing 15% EtOH-induced increases in intraduodenal pressure (motility).

<p>All rats were pretreated with i.v. parecoxib 10 mg/kg approximately 60 min before the experiment started to reverse surgery-induced paralytic ileus. <b>A)</b> Saline perfusion with migrating motor complex (MMC) pattern. <b>B)</b> Luminal 15% EtOH increased motility. <b>C)</b> Continuous i.v. infusion of NPS reduced basal motility (time 0–30 min) and the motility effect of 15% EtOH. <b>D)</b> NPS at 10× concentration further decreased basal motility (time 0–30 min) and further dampened the effect of 15% EtOH.