MRI volumetric analysis in both studied groups (Sham and HI group), using the BioSpec 94/30 imaging system is a 9.4T horizontal bore magnet operates at 400 MHz and runs ParaVision^™ 4.0 software.

<p><b>Panel A:</b> Coronal (top) and axial (bottom) brain slices. <b>Panel B:</b> lateral ventricle volume bilaterally measured by paravision software in both studied groups. <b>Panel C:</b> Brain volume includes brain volume + lateral ventricle volume measured by paravision software in the studied groups. <b>Panel D:</b> The ratio of bilateral lateral ventricle volume to total brain volume measured by paravision software in the studied groups. Since there was no significant difference in brain volume, increased lateral ventricle volume indicates white matter loss. N = 10 animals/group. Bars represent the Mean + SE. * indicates P< 0.05.