Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection - Fig 2

<p>Panel A: The basic viral dynamics model, in which therapy blocks the production of virus, yields a biphasic viral decline pattern, but is not able to reproduce the complete set of kinetic patterns observed here for the effect of ganciclovir on CMV. Panel B: The novel viral dynamics model developed here for ganciclovir’s effect on CMV replication. In this model the intracellular negative feedback loop between UL97 and ganciclovir is explicitly modeled. Variable key (full description in the <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006299#sec009" target="_blank">Methods</a> section): <i>T</i> = target cells, <i>I</i> = infected cells, <i>V</i> = free virus, <i>U</i> = intracellular UL97 enzyme concentration, <i>G</i>_<i>o</i> = intracellular ganciclovir concentration, <i>G</i>_<i>3</i> = intracellular concentration of the active tri-phosphorylated form of ganciclovir, <i>D</i>_<i>1</i> = intracellular linear/circular/concatemeric forms of viral DNA, <i>D</i>_<i>2</i> = intracellular cleaved/packaged viral DNA, <i>WB</i> = whole blood viral load, <i>ε</i> = drug efficacy.