Model for feedback control of GSC proliferation.

<p>Arrows represent activation and bars represent inhibition. The dotted lines represent the delay between the coupling of oocyte maturation/ovulation and the regulation of MPK-1 in zone I due to the time required for oocyte accumulation or its relief. Note that MPK-1 activity could regulate GSC proliferation indirectly through affecting pachytene progression (as represented), but also potentially through a parallel mechanism. Also note that we placed <i>par-5</i> downstream of <i>aak-1</i>, but this is purely due to the overlap between the two proteins consensus target motif.