Correlation between the CXCR4 binding characteristics of the compounds and their potency to inhibit CXCL12/CXCR4 signaling and function.

<p><b>(A), (B), (C) and (D):</b> Correlation between the IC₅₀ value of the compounds for CXCL12 receptor binding inhibition and inhibition of (A) CXCL12-induced calcium signaling (p<0.0001; R² = 0.95), (B) CXCR4 internalization (p<0.0001; R² = 0.96), (C) chemotaxis (p<0.0001; R² = 0.84) and (D) HIV viral entry (in MT-4 cells) (p = 0.0002; R² = 0.81). The maximum test concentration of CTCE-9908, WZ811, Me6TREN and gambogic acid is represented when no activity was detected. Correlations were calculated in Graphpad using the Pearson correlation test (p-values < 0.05 were considered as statistical significant).