SOD1 deficiency and the HM/LF diet produce an additive increase in endothelial dysfunction and induce a non-additive decrease in vasodilator responses to nitroprusside and papaverine.

<p>Dilatation of cerebral arterioles to acetylcholine (10⁻⁶ M [A] or 10⁻⁵ M [B]), nitroprusside (10⁻⁸ M [C] or 10⁻⁷ M [D]), and papaverine (10⁻⁶ M [E] or 10⁻⁵ M [F] was measured in <i>Sod1+/+</i>, <i>Sod1+/-</i>, and <i>Sod1-/-</i> mice on either control or HM/LF diet (n = 7–10 mice per group). Values are mean ± SEM. *P<0.01 compared to control diet; # P < 0.05 compared to <i>Sod1+/+</i> on the same diet.