<p>(A) Secondary structure. (B) Tertiary structure. The bound theophylline molecule is colored magenta. (C) Theophylline structure. Depicted RNA structures are based on the first conformer of PDB entry 1EHT. Secondary structure diagram was generated by the RNApdbee webserver[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0176229#pone.0176229.ref088" target="_blank">88</a>].</p
Since the early 2000s, nucleic acid aptamers have gained considerable attention of life science comm...
RNA is an underutilized target for drug discovery. Once thought to be a passive carrier of genetic i...
Metal ions are critical for RNA structure and enzymatic activity. We present the structure of an asy...
RNA aptamers are oligonucleotides that bind with high specificity and affinity to target ligands. In...
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using smal...
The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibioti...
The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibioti...
Aptamers are short, single-stranded nucleic acids with structures that frequently change upon ligand...
AbstractBackground: Structural studies by nuclear magnetic resonance (NMR) of RNA and DNA aptamer co...
<p>(Figure adapted from ref. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone....
The research in this Ph.D. thesis is part of an ongoing effort to improve our understanding of RNA s...
Mucin 1 is a well-established target for the early diagnosis of epithelial cancers. The nucleotides ...
RNA is able to bind small molecule (MW <2000) ligands. These ligands can be drugs that bind to si...
Pepper is a fluorogenic aptamer tag that is able to bind a variety of benzylidene-cyanophenyl (HBC) ...
The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitor...
Since the early 2000s, nucleic acid aptamers have gained considerable attention of life science comm...
RNA is an underutilized target for drug discovery. Once thought to be a passive carrier of genetic i...
Metal ions are critical for RNA structure and enzymatic activity. We present the structure of an asy...
RNA aptamers are oligonucleotides that bind with high specificity and affinity to target ligands. In...
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using smal...
The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibioti...
The tetracycline-binding RNA aptamer (TC-aptamer) is a synthetic riboswitch that binds the antibioti...
Aptamers are short, single-stranded nucleic acids with structures that frequently change upon ligand...
AbstractBackground: Structural studies by nuclear magnetic resonance (NMR) of RNA and DNA aptamer co...
<p>(Figure adapted from ref. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone....
The research in this Ph.D. thesis is part of an ongoing effort to improve our understanding of RNA s...
Mucin 1 is a well-established target for the early diagnosis of epithelial cancers. The nucleotides ...
RNA is able to bind small molecule (MW <2000) ligands. These ligands can be drugs that bind to si...
Pepper is a fluorogenic aptamer tag that is able to bind a variety of benzylidene-cyanophenyl (HBC) ...
The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitor...
Since the early 2000s, nucleic acid aptamers have gained considerable attention of life science comm...
RNA is an underutilized target for drug discovery. Once thought to be a passive carrier of genetic i...
Metal ions are critical for RNA structure and enzymatic activity. We present the structure of an asy...