Additional file 2: of Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells

In vitro inhibition of HOAC viability by carboplatin in combination with kinase inhibitors. HOACs were treated with a dose range of carboplatin (Ca) in combination with dose range of Crizotinib (Cr), Dasatinib (Da) or Gefitinib (Ge) based on a ratio of the IC50 of the two drugs. The IC50 of each drug are plotted on the axes and the circle represents the concentrations of each drug resulting in 50% of cell viability inhibition (Fa = 0.5). The solid line represents the additive effect. A synergistic combination is plotted on the left of the solid line while an antagonistic combination is plotted on the right. Isobolograms were generated with the CompuSyn 1.0 software. (PDF 39 kb