Histological and biochemical analysis of the FAAH enzyme in the striatum of SCA-3 transgenic and wild-type mice.

<p><u>Panels A and B</u>: qPCR analysis and Western blot quantification (in a representative blot) of the FAAH enzyme in the striatum of SCA-3 transgenic and wild-type mice at different stages of disease progression. <u>Panels C and D</u>: Immunostaining for the FAAH enzyme in the striatum of SCA-3 transgenic and wild-type mice at different stages of disease progression (bar = 50 μm). Arrows indicate stronger immunolabeling in surviving striatal neurons of SCA-3 transgenic mice. In all cases, the values are expressed as the mean ± SEM of more than 6 animals <i>per</i> group, assessing the data using a Student’s t-test: *p<0.05, **p<0.01 <i>versus</i> wild-type animals.