Quality assessment of the social defeat model.

<p><b>(A)</b> Significant decreases in body weight were found inthe socially defeated group (n = 9) compared with the control group (n = 8). In the FST, the socially defeated group showed a significant decrease in sucrose preference <b>(B)</b> and sucrose consumption <b>(C)</b> compared with the control group. In the OFT, socially defeated rats did not significantly differ from control rats in total distance <b>(D)</b>, time spent in center <b>(E)</b> and number of rearing behaviors <b>(F)</b>. In the EPM, there were no significant differences between two experimental groups, including frequency <b>(G)</b> and time <b>(H)</b> spent in open arms, as well as in closed arms <b>(I, J)</b>. In the FST, longer immobility time was found in socially defeated rats <b>(K)</b>. *<i>P</i>< 0.05.