Dissimilar induction of innate and adaptive immunity by Type A and B LPS in RAW264.7 macrophages.

<p>Macrophages were treated for 2 h with either 10 ng/mL Type A or Type B LPS before isolation of total RNA. Gene expression profiles were assessed using innate and adaptive mouse RT² Profiler qPCR arrays. Panels A and B show genes that are either upregulated more than 2-fold (red dots) unchanged (black dots) or downregulated more than 2-fold (blue dots) in response to macrophage treatment with Type A LPS (derived from 1026b) or Type B LPS (derived from 576a), when compared to untreated macrophages. C), Heat-map of all genes analyzed and grouped by expression trends. Genes with significantly different expression are listed in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0005571#pntd.0005571.s002" target="_blank">S1 Table</a>.