Implantation of HGF-modified skeletal myoblasts reduces infarct area and reduces collagen deposition.

<p>The Ad-GFP- or Ad-HGF-transduced myoblasts were implanted into the myocardium in an MI model for 28 days. (a) Representative images of histological sections in left ventricular stained with HE. Scale bars, 1 mm. (b) Images show that Sirius Red stained the cardiac sections from SM-GFP, SM only, SM-HGF group, and sham group, respectively. (c) The collagen volume fraction of SM-HGF group compared to the control group and SM group (n = 6, P<0.05, *P<0.05 vs. SM group; ^#P<0.05 <i>vs</i>. SM-GFP group; ^†P<0.05 <i>vs</i>. control group).