Pharmacological inhibition of Akt in <i>PTEN</i> corrected cells.

<p>(a) Cell proliferation results for 42MBGA cells and <i>PTEN</i> corrected derivatives (#7–17, #7–24) cultured in 1% serum either with (+) or without (-) MK-2206. Pharmacological inhibition of Akt inhibits cell proliferation in <i>PTEN</i> mutant 42MGBA cells but not in their isogenic <i>PTEN</i> corrected derivatives. (b) Cell proliferation results for T98G cells and <i>PTEN</i> corrected derivatives (#5–18, #5–28) cultured in 10% serum either with (+) or without (-). 500 cells were plated per well.