Sequence alignment of human, chimpanzee, and rat CD81s.

<p>The sequence alignments of full-length human and chimpanzee CD81s display 100% identity, whereas that of human and rat CD81s show over 93% identity (97% similarity). The sequence identity of the LEL between humans and rats is 84% (93% similarity) and that of the transmembrane domain is 99%, indicating that the major differences between human and rat CD81s are in the LEL. The transmembrane domain at a.a. 1–112 and 202–236 is indicated with a green rod, whereas the LEL region at a.a. 113–201 is indicated with a red rod. The largest differences between the CD81s located within 160–190 a.a are within the black–framed box.