Effects of silencing the expression of <i>BCL-XL</i> variants in various transgenic strains and control worms.

<p><b>A)</b> RNAi efficiency, <b>B)</b> total viable progeny and <b>C)</b> percentages of eggs hatched, <b>D)</b> mitotic regions and <b>E)</b> transition zones, <b>F)</b> chromosome stability and aneuploidy, <b>G)</b> germline apoptosis of the gonads and <b>H)</b> lifespan. Each point in graph (<b>B to G</b>) represent data obtained from single worm. Bars are means ± s.d. Brackets on top of graph <b>(B to G)</b> indicate statistical significance with <i>p<0</i>.<i>05</i> between worms subjected to control RNAi (-) and <i>BCL-XL</i> RNAi (+). Statistical significance for <b>H)</b> is indicated in graph legend. Typical micrographs are showed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0177413#pone.0177413.s003" target="_blank">S3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0177413#pone.0177413.s004" target="_blank">S4</a> Figs.