Effects of a chronic administration of E2, P4 and combined treatment on the uteri and vagina of mice.

<p><b>(A)</b> Uterine weights, epithelial proliferation and luminal epithelial height after the different treatments. Representative sections from uterus stained with Ki-67 antigen. <b>(B)</b> Vagina weights, epithelial proliferation and luminal epithelial height after the different treatments. Representative sections from vagina stained with Ki-67 antigen are shown. <b>(C)</b> Vaginal lubrication (mg). Data are presented as mean ± SD. To test the respective roles of each treatment, a one-way ANOVA was performed and a Bonferroni’s multiple comparison test. * t test vs OVX. $ t test vs E2.