Genetic principal component analyses of individuals used in the validation study to investigate the relationship between Mapuche proportions and gallbladder cancer risk, using Mapuche and Aymara individuals as surrogates of the two largest indigenous peoples in Chile (panels A-C).

<p>Gallbladder cancer cases are represented by black dots and unaffected subjects by grey dots. Fig 4D represents the pedigrees of the four families included in the validation study (Gallbladder cancer cases genotyped in the study are represented by black dots, unaffected genotyped subjects by grey dots, non-genotyped gallbladder cancer cases by red dots and unaffected non-genotyped subjects by empty circles).